Investigative Efforts

Included on this web page are the most important ongoing, recently completed or terminated clinical trials addressing topics in perioperative geriatric medicine, all available at www.clinicaltrials.gov. A list of recent FAER grants addressing geriatric medicine is also included.

Postoperative Cognitive Dysfunction in Geriatric Patients

Cognitive dysfunction in this context includes delirium, dementia, memory and cognitive disorders.

Postoperative Cognitive Dysfunction in Geriatric Patients

Estrogen Replacement to Reduce Risk of Neurologic Injury After Coronary Artery Bypass Graft Surgery

Cognitive Protection - Dexmedetomidine and Cognitive Reserve

Xenon Inhalation During Orthopaedic Surgery in Elderly Subjects

Brain Oxygenation Monitoring in Patients Undergoing Coronary Artery Bypass Surgery

Continuous Cellsaver and Neurocognitive Decline Post Cardiac Surgery

Donepezil in Preventing Delirium in Hospitalized Elderly

Effect of Usage of EEG Entropy on the Incidence of Postoperative Cognitive Dysfunction in Geriatric Patients

n-3 Enriched Nutrition Therapy and Postoperative Cognitive Dysfunction After Cardiac Surgery

Incidence and Predictors of Delirium After Cardiac Surgery (IPDACS)

A Research Study to Evaluate the Effectiveness of Dexmedetomidine in Preventing Delirium After Heart Surgery

Rivastigmine for the Prevention of Postoperative Delirium in Patients Undergoing Cardiac Surgery

Short-term Atorvastatin's Effect on Acute Kidney Injury Following Cardiac Surgery

A Research Study to Evaluate the Effectiveness of Dexmedetomidine in Preventing Delirium After Hip Fracture Repair Surgery

Prevalence of Delirium in Patients Undergoing Cardiac Surgery

Risk Factors of Recovery Room Delirium After Elective Non-cardiovascular Surgery

Post-operative Haloperidol Versus Placebo for Prevention of Post-operative Delirium After Acute Hip Surgery

Is Dexmedetomidine Associated With a Lower Incidence of Postoperative Delirium When Compared to Propofol or Midazolam in Cardiac Surgery Patients

Organ Protection for CABG: Propofol Versus Desflurane

Does APOE-e4 Predict Delirium and Cognitive Dysfunction After Surgery?

Supporting the Health of Adults Undergoing Orthopedic Surgery During the Recovery Period (SHARP)

Role of Absolute Cerebral Oximetry to Prevent Neurocognitive Injury in Elderly Patients Undergoing Cardiac Surgery

Prophylactic Olanzapine Versus Placebo for Prevention of Postoperative Delirium After Joint Replacement Surgery

Pregabalin in the Prevention of Postoperative Delirium and Pain

Effects of Steroids, Controlling Blood Sugar Levels, and Avoidance of Deep Anesthesia on Patient Outcomes After Major Vascular Surgery (DeLiT)

A Placebo Controlled Trial of L-Tryptophan in Post-Operative Delirium

Interaction of Cobalamin Status With Nitrous Oxide in Relation to Postoperative Cognitive Changes in the Elderly

Prevention of Postoperative Delirium With Donepezil

Perioperative Cognitive Function - Dexmedetomidine and Cognitive Reserve

Postanesthesia Cognitive Recovery and Neuropsychologic Complications

Incidence of Delirium in Hip Fracture Patients Randomized to Regular Hypnotics vs. Placebo

Affect of Different Types of Anesthetic Techniques on Cognition in Patients With Parkinson's Disease

Sedation and Delirium in Elderly Hip Fracture Patients (BIS)

Namenda to Prevent Post-Operative Delirium

Postoperative Delirium at Heidelberg's Intensive Care Unit - New Diagnostic Markers

Gabapentin for Postoperative Pain Management After Cardiac Surgery With Median Sternotomy

A Study to Determine if Carbon Dioxide Lavage During Total Knee Surgery Reduces Intraoperative Embolic Events

Cognitive Effects of Inhalational Versus Intravenous General Anesthesia in the Elderly

Postoperative Cognitive Decline, Inflammation, and Plasma Levels of Beta-Amyloids

Physostigmine After General Anesthesia

Postoperative Functional Impairment in Geriatric Patients

Functional impairment in this context is physical impairment.

Elder Surgery - Functional Recovery Following Beta Blockade

Performance Evaluation and Research for Older Adults Requiring Major Surgery (PERFORM)

Muscle Function in Elderly Postoperative Patients

Surgical Risk in Geriatric Patients

Evaluation of Surgical Risk in Elderly Patients Submitted to Elective Surgery

Randomized Trial of a Liberal Versus a Restrictive Transfusion Strategy in Elderly Cardiac Surgery Patients

Prognostic Value of New Cardiac Biomarkers in Elderly Patients Undergoing Cardiac Surgery

Evaluation of Postoperative Blood Pressure Changes After Benign Gynecologic Surgery

Transfusion Requirements in Orthopedic Surgery (PHASE 2) (TRIOS)

Clinical Observational Study Investigating the Role of Diastolic Dysfunction in Determining Abnormal Cardiorespiratory Exercise Testing Parameters in Patients Undergoing Major Surgery

Remote Ischaemic Preconditioning for Heart Surgery (RIPHeart-Study)

A Prospective, Randomized, Double-Blinded Study of the Effect on Improved Recovery Using the SEDLine TM for the Titration of Sevoflurane in Elderly Patients Undergoing Non-Cardiac Surgery After Beta-Adrenergic Blockade

The Effect of Taurine on Morbidity and Mortality in the Elderly Hip Fracture Patient (TAUP)

Cognitive Effects of Bariatric Surgery

Postoperative Pain and Rehabilitation

Safety and Efficacy Study of Intravenous Lidocaine After Colorectal Surgery: LIDOREHAB

Effect of Combined Use of Naloxone and Tramacet on Postop Analgesia in Elderly Patients Having Joint Replacement Surgery

Hypnosis for Eye Surgery

Improving Pain and Function in Hip Fracture

Mind Body Therapy During Geriatric Rehabilitation

Intervention Program for Elderly Patients With Hip Fracture

Clinical Trial of Gabapentin to Improve Postoperative Pain in Surgical Patients

Recent FAER Grants Addressing Geriatric Medicine

Benjamin T. Houseman, MD, PhD, University of California, San Francisco, 2009 Mentored Research Training Grant, “Pharmacologic Dissection of the Phosphoinositide-3-Kinase Pathway in Cardiac Preconditioning and Postconditioning."

Michael L. James, MD, Duke University Hospital, 2009 Mentored Research Training Grant, "Pharmacogenomic Influence of ApoE and Mimetic Peptide on Neurologic Outcomes as a Paradigm for Targeted Therapeutic Development in a Murine Model of Intracerebral Hemmorrhage.”

Tobias Eckle, MD, PhD, University of Colorado, 2008 Mentored Research Training Grant, “Myocardial Ischemic Preconditioning through Hypoxia Inducible Factor (HIF)-1α.”

Jutta Novalija, MD, PhD, Medical College of Wisconsin, 2008 Mentored Research Training Grant, “Anesthetic Protection of Endothelial Function from Ischemia-Reperfusion Injury in Humans.”

Sarah Cheng, MD, PhD, University of Colorado Health Sciences Center, 2007 Research Fellowship Grant, “Goal-directed Therapy for VTE Prophylaxis in the Surgical ICU.”

Amanda A. Fox, MD, Brigham and Women’s Hospital (MA), 2007 Research Starter Grant, “Genotypic Influences on Postoperative B-Type Natriuretic Peptide Concentration and Ventricular Dysfunction with Coronary Artery Bypass Graft Surgery.”

Lixin Liu, MD, PhD, Stony Brook University Hospital in New York, 2007 Research Starter Grant, “Age-Associated Changes in Cardiac Gene Expression Following Anesthestic Preconditioning.”

Hannah Wunsch, MD, MSc, Columbia University (NY), 2007 Research Fellowship Grant, “Evaluation of Long-Term Outcomes for Intensive Care Patients.”

Brian M. Ilfeld, MD, University of Florida, 2005 Mentored Research Training Grant, “Perineural Local Anesthetic Infusion Following Total Knee and Hip Replacement.”

Pratik P. Pandharipande, MD, Vanderbilt University (TN), 2005 Mentored Research Training Grant, “A Randomized, Double-Blind Trial in Ventilated ICU Patients Comparing Treatment with an Alpha2 Agonist Versus a Gamma Aminobutyric Acid (GABA)-Agonist to Determine Delirium.”

Greg Strathmann, MD, PhD, University of California, San Francisco, 2005 Mentored Research Training Grant, “The Role of Neurogenesis in the Young and Old Brain in Mediating Cognitive Outcome Following Anesthesia.”

Ken Brady, MD, Johns Hopkins University (MD), 2004 Research Fellowship Grant, “The Role of Cytosolic Phospholipase A2-a in Stroke Pathogenesis.”

Lorri A. Lee, MD, University of Washington, 2004 Research Starter Grant, “Effects of Hypovolemia, Deliberate Hypotension, Anemia and Venous Congestion on Optic Nerve Blood Flow in the Pig.”

NOTE: The information in this clearinghouse is provided as a public service, but is not endorsed by FAER. It is reviewed periodically to ensure content is current, but some information may be obsolete. If you discover obsolete information in this clearinghouse, or if you have information you think should be included, please contact FAER Programs Coordinator Nicole Ferrara at ferrara.nicole@mayo.edu.